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MOA of Fever (Pyrexia) in Points Fever = regulated rise in body temperature due to an increased hypothalamic set point. Infection/inflammation occurs. Immune cells release pyrogenic cytokines: IL-1 IL-6 TNF-α These cytokines stimulate production of Prostaglandin E2 (PGE2). PGE2 acts on the hypothalamus and raises the temperature set point. The body now perceives its current temperature as too low. Vasoconstriction reduces heat loss. Shivering increases heat production. Metabolic activity increas
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The animation shows 146 years of temperature in the contiguous United States, 1880 to 2025. Each year displays how far that year's average temperature was above or below the 1901–2000 average. The country then squeezes into a single bar and drops into the strip at the bottom, where it becomes that year's stripe, colored by the national average. By the end, the strip shows the whole record at once: mostly blues and pale tones through the first half of the 20th century, a mixed middle, then a run
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