Buffalo Bills receiver Amari Cooper has called his team "scary" after the 35-10 win over the San Francisco 49ers.

San Francisco 49ers star left tackle Trent Williams’ newborn son passed away last week, his wife Sondra announced on ...

Head coach Kyle Shanahan shared the latest injury and team updates emerging from the San Francisco 49ers Week 13 matchup ...

McCaffrey suffered a PCL injury during Sunday's loss to the Bills, while Mason goes on IR with a high ankle sprain.

Parts of the Great Lakes region are seeing new snow and face the prospect of even more this week after U.S. travelers battled ...

San Francisco 49ers head coach Kyle Shanahan spoke with reporters during a conference call on Monday, the day after the ...

San Francisco 49ers head coach Kyle Shanahan revealed Sunday night that the team fears running back Christian McCaffrey ...

The Miami Dolphins' Week 16 matchup against the San Francisco 49ers at Hard Rock Stadium is losing luster by the minute. What ...

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and San Francisco 49ers.

Quarterback Josh Allen and coach Sean McDermott deserve credit in overcoming lowered expectations in leading the Buffalo ...

The 49ers — who were already without Trent Williams, Nick Bosa and Deommodore Lenoir — saw Christian McCaffrey leave their ...

How will the Eagles fare in a playoff atmosphere? They passed a test on Sunday with perhaps their most impressive win. And ...