Is Pro Football Talk’s Mike Florio just sort of scatter-shooting when he says he believes San Francisco is suddenly once again is a top-five powerhouse in its conference?

The San Francisco 49ers need star running back Christian McCaffrey to be healthy for the entirety of this season to recapture the NFC West crown.

How does the classic saying go? Look good, feel good, play good? That expression cannot be more true than it is in the NFL. Throughout the league’s 100+ year ...

Getting McCaffrey back to full strength is one of the most important developments of the offseason for the 49ers. After ...

The Utes, as usual, have the most former players in the NFL among Utah schools, while the Cougars are second — though by a ...

In a nationally televised game featuring the Bills against the visiting San Francisco 49ers, NBC viewers were treated to a winter wonderland. Lake effect conditions in western New York had state ...

"Sunday Night Football" in Week 13 sees the San Francisco 49ers taking on the Buffalo Bills. Here's the latest on a snowy forecast for the game.

It was December football Sunday night in Buffalo. Playing in below-freezing temperatures and in the snow, the Buffalo Bills (10-2) defeated the San Francisco 49ers (5-7), 35-10, at Highmark Stadium.

Just because Bills players live in Buffalo doesn’t mean they’re accustomed to playing football with inches of snow on the ground. They just handled the conditions much better than the 49ers.

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been tabbed a potential Super Bowl preview. Only one of the prime-time foes ...

Stay here all evening for live updates: Final score: Buffalo Bills 35, San Francisco 49ers 10 Buffalo has won five straight AFC East titles. The Bills cruised to a blowout over the 49ers.

Buffalo Bills quarterback Josh Allen was credited with two passing scores, a rushing touchdown and a receiving touchdown in a win over the San Francisco 49ers on Sunday in Orchard Park, N.Y. File ...