The Buffalo Bills clinched their record fifth consecutive AFC East title Sunday night after defeating the 49ers 35-10 on ...

San Francisco 49ers running back Jordan Mason is going on injured reserve, head coach Kyle Shanahan announced.

The Highmark Stadium was covered in snow during the Buffalo Bills game against San Francisco 49ers on Sunday (01/12).

Lake-effect snow continued to fall on parts of western New York that were already blanketed with a foot or more over the past ...

In eight season’s San Francisco 49ers tight end George Kittle never played in Buffalo at Highmark Stadium. Despite the loss ...

The heavy lake effect snow prompted the Buffalo Bills to ask fans for help clearing snow out of Highmark Stadium ahead of the ...

San Francisco 49ers quarterback Brock Purdy appears to be making strides in his recovery from a shoulder injury. During the ...

Bills quarterback Josh Allen and head coach Sean McDermott celebrated by making snow angels after Buffalo clinched its fifth ...

Here are your top 49ers storylines for Monday, December 2nd.

A Buffalo Bills fan was shirtless in below freezing temperatures and jumping in snow during the team's win over the 49ers.

Two Erie County Sheriff’s deputies were not injured after they were hit by a truck in the area of Highmark Stadium early Monday, police said. A vehicle going westbound ...

Parts of the Great Lakes region saw new snow Monday and faced the prospect of even more this week after U.S.