The Bills (10-2) ended up winning in a rout in a 35-10 final over the 49ers (5-7). That was just the start of it. On a ...

It's Buffalo Bills vs San Francisco 49ers in Week 13 of the NFL season. Can Josh Allen and company outduel Christian McCaffery and Deebo Samuel?

The Bills and the San Francisco 49ers went head-to-head in freezing conditions Sunday, with Bills fans and staff digging out ...

In Sunday's 35-10 win over the San Francisco 49ers, The Buffalo Bills used Alec Anderson as a third tackle on 17 plays, and ...

In a 35-10 win over the San Francisco 49ers at home in Orchard Park, HC Sean McDermott’s record coming out of the bye week remained perfect and the Buffalo Bills looked the part of a playoff contender ...

Quarterback Josh Allen and coach Sean McDermott deserve credit in overcoming lowered expectations in leading the Buffalo ...

Back-to-back blowout losses and another injury to star back Christian McCaffrey might just be the final blow to the dwindling ...

Buffalo Bills fans embraced the snowy conditions at Highmark Stadium in Orchard Park, New York, on December 1, as their team ...

The 49ers' playoff hopes are essentially dead now, and it became that way once McCaffrey went down with an unknown injury. On ...

The Great Lakes experienced a surge of activity as arctic air passed over record-warm waters, generating prolific snowfall.

There's even a chance Guerendo, who pulled his hamstring on the first day of training camp and missed the first two preseason ...

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...