A new review highlights how synthetic biology, AI, and spatial omics could transform ligand-receptor discovery from one-by-one searches into network-level mapping.

Substance P is a member of the tachykinin family of neuropeptides, characterised by an eleven-amino-acid sequence that is highly conserved across mammalian species. It exerts its effects primarily ...

Iron is indispensable for oxygen transport, DNA synthesis and energy production, yet free iron is potentially toxic. Cellular uptake of iron is primarily mediated by the transferrin receptor (TfR), ...

Edited by Karen Young Kreeger J.A. Bennett, R. Dingledine, "Topology profile for a glutamate receptor: Three transmembrane domains and a channel-lining reentrant membrane loop," Neuron, 14:373-84, ...

The human P2X4 receptor plays an important role in chronic pain, inflammation and some types of cancer. Researchers at the University of Bonn and the University Hospital Bonn (UKB) have now discovered ...

All cells, whether big or small, short or long, rely on proteins to function properly. In most cells, transporting these ...

New AI‑designed miniproteins precisely modulate GPCR signaling and reveal a new screening system for targeting receptors long ...

"I think PAGER has potential for impact, both in the G protein coupled receptor biology field, and in synthetic circuits or cell-based therapies," said Alice Ting, professor of genetics at the School ...

Tweaking the numbers of receptors in a key brain area changes the daily rhythms of rest and wake in mice. In humans and other animals, signals from a central circadian clock in the brain generate the ...

Chronic itch is often described as an "invisible torment." It can persist for weeks or months, severely affecting sleep, ...

Researchers at the Harrington Discovery Institute have identified cellular mechanisms involving Golgi apparatus proteins that ...