What Are the Causes of Degenerative Myelopathy in Dogs? DM is caused by inherited changes to a gene called superoxide dismutase 1, or SOD1.

In this phase 3 trial, we randomly assigned adults with SOD1 ALS in a 2:1 ratio to receive eight doses of tofersen (100 mg) or placebo over a period of 24 weeks. The primary end point was the ...

Research Summary Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS DOI: 10.1056/NEJMdo006684 Save ...