Open Heart

Causal relevance of clonal haematopoiesis with cardiac disease and adverse remodelling: a Mendelian randomisation study

Background Many observational studies highlight clonal haematopoiesis (CH) as a novel determinant of cardiovascular disease ...
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Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial

Objective To test the effectiveness of an impedance cardiography (ICG) guided treatment strategy on improving blood pressure (BP) control in real-world clinical practice. Design A single-centre, ...
openheart.bmj

Global, regional and national burdens of cardiovascular disease attributable to secondhand smoke from 1990–2019: an age-period-cohort analysis

Background Over the past three decades, significant disparities in the global burden of cardiovascular disease (CVD) have been observed, particularly CVD attributed to secondhand smoke. However, a ...
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Comparative efficacy and safety of aldosterone synthase inhibitors in hypertension: a Bayesian network meta-analysis of randomised controlled rials

Introduction Resistant hypertension remains a clinical challenge, often linked to elevated aldosterone levels not fully controlled by mineralocorticoid receptor antagonists. Aldosterone synthase ...
openheart.bmj

Withdrawing guideline-directed medical therapy after left ventricular ejection fraction recovery following atrial fibrillation ablation: a multicentre cohort study

Background Atrial fibrillation (AF)-induced cardiomyopathy (AIC) is characterised by reversible left ventricular (LV) dysfunction after restoration of sinus rhythm (SR). The need for continued ...
Open Heart

Association between atherogenic index of plasma and incident aortic disease: a population-based prospective analysis

Objective To clarify whether atherogenic index of plasma (AIP), a comprehensive indicator reflecting both the protective and ...
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Phenotyping of patients with mild pulmonary hypertension

Background Revised haemodynamic criteria for pulmonary hypertension (PH)—mean pulmonary artery pressure (mPAP) >20 mm Hg and pulmonary vascular resistance (PVR) >2 Wood Units (WU)—have defined new ...
openheart.bmj

Trends in the incidence and prevalence of cardiac pacemaker insertions in an ageing population

Objectives To determine contemporary population estimates of the prevalence of cardiac permanent pacemaker (PPM) insertions. Methods A population-based observational study using linked hospital ...
openheart.bmj

Sudden cardiac death after acute myocarditis with arrhythmic presentation: hunting for risk predictors − a systematic review and meta-analysis

Background Ventricular arrhythmias (VAs) frequently occur in the acute phase of myocarditis. Possible arrhythmic recurrences and the risk of sudden cardiac death (SCD) in this setting are reasons for ...
openheart.bmj

Observational analysis of non-ST-segment elevation myocardial infarction invasive management and mortality over the decades

Background Routine invasive management by coronary angiography and revascularisation as appropriate reduces recurrent ischaemic events in non-ST-segment myocardial infarction (NSTEMI), but its ...
openheart.bmj

Clarification of embolic source in ischaemic stroke by non-obstructive general angioscopy

Background Aortogenic stroke is an important subtype of embolic strokes, yet lacks a diagnostic method for proactive identification. Non-obstructive general angioscopy (NOGA) is a catheter-based ...