The Sistine Chapel, a sacred room in the Apostolic Palace in Vatican City, is one of the most famous chapels in the world—and this week, cardinals from around the world will gather inside to choose a new pope.

As the papal conclave is set to begin to elect a new pope, the eyes of the world are on the Sistine Chapel, which will hold the Catholic cardinals as they cast their votes for the next leader of the Church.

The conclave to select the next pope has begun after Catholic cardinals from across the world filed into the Sistine Chapel Wednesday before sealing themselves inside.