McCaffrey made history again in Monday’s game, prompting a big announcement from the NFL.

It was Christian McCaffrey who stole the show in Monday’s primetime matchup. The two-time All-Pro running back registered 24 ...

With a win tonight, the 49ers’ odds of making the playoffs move from 83 percent from 89 percent in The Athletic’s NFL Playoff ...

The Carolina Panthers and the San Francisco 49ers take the field for NFL Monday Night Football tonight in Week 12. MNF start ...

The San Francisco 49ers (7-4) will take on the Carolina Panthers (6-5) at Levi Stadium in Santa Clara, California, on Monday, ...

The San Francisco 49ers (7-4) host the Carolina Panthers (6-5) on Monday Night Football in a key battle for NFC playoff ...

Thanks in large part to a stellar defense and a workhorse performance by Christian McCaffrey, the 49ers were able to overcome ...

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Catch Bryce Young and the Panthers (6-5) against Brock Purdy and the 49ers (7-4) at 8:15 p.m. ET on ESPN with streaming ...

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The 49ers and Panthers will round out the NFL's Week 12 slate in primetime on Monday night, as former Mr. Irrelevant Brock ...

Brock Purdy, Christian McCaffrey and the San Francisco 49ers host the Carolina Panthers led by quarterback Bryce Young on ...