techexplorist1d
Uncovering the genetic basis of rare mutations in Alzheimer’s disease
Alzheimer’s disease is a progressive condition that impairs memory and cognitive function, affecting millions globally.
Reserch sheds light on how mutated PSEN2 accelerates familial Alzheimer's disease progression
Alzheimer's disease is a debilitating condition that slowly robs people of their memory and cognitive abilities, affecting millions of people worldwide.
EurekAlert!1d
The genetic roots of rare mutations in Alzheimer’s disease
Alzheimer’s disease is a debilitating condition that slowly robs people of their memory and cognitive abilities, affecting millions of people worldwide. Familial Alzheimer’s disease (FAD), a rare ...
Hosted on MSN5h
New Insights into the Mechanisms Driving Familial Alzheimer's Disease
Millions of people worldwide suffer from Alzheimer's disease, a crippling illness that gradually robs people of their memory and cognitive abilities.
inceptivemind1d
The genetic basis of rare mutations in Alzheimer’s disease
Familial Alzheimer's disease (FAD), a rare inherited form of the condition, is associated with mutations in several genes, ...
Nature9d
Membrane trafficking articles from across Nature Portfolio
This latest research reveals that changes in PSEN2 expression accelerate amyloid build-up, disrupt lysosomal function, and weaken synaptic connections. These findings spotlight PSEN2 as a powerful ...
precisionmedicineonline28d
International Working Group Says Biomarkers Aren't Enough to Diagnose Alzheimer's
and PSEN2 that are associated with Alzheimer's. Mutations in these genes are known to cause a form of early-onset familial Alzheimer's, characterized by patients experiencing dementia before age 65.
eLife8d
Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production
This manuscript provides fundamental studies to help us better understand the effects of mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP).