Should Guerendo start as expected Sunday, it will be just his second start as a running back since he was in the fourth grade ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

Kyle Shanahan explains why 49ers rookie Isaac Guerendo is ready to be the starter with Christian McCaffrey and Jordan Mason ...

Henry will be the only must-start member of this backfield when they return in Week 15 to face the Giants. James Cook (Week ...

During Sunday Night Football against the Bills, Isaac Guerendo punched in his second touchdown of his rookie campaign.

Christian McCaffrey and Jordan Mason both landed on IR after the 49ers lost to the Bills in Week 13. Isaac Guerendo will now ...

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Since Week 7, Wilson is 11th in EPA per play and fourth in CPOE. Wilson and the Steelers face a Browns defense that has faded ...

Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.