Since training camp, the 49ers season hasn't gone as planned amid injuries to star players and on-field struggles.

On Thursday night, the San Francisco 49ers will host the Los Angeles Rams at Levi's Stadium in what is a must-win game for them and their playoff hopes.

San Francisco 49ers running back Christian McCaffrey was the near-consensus No. 1 pick in fantasy football drafts. However, ...

San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

How high did the Dolphins and 49ers rise and how far did the Bears fall in our Week 15 Power Rankings? Plus, we look at the ...

McCaffrey's old backfield mate discussed the trials and tribulations of a season-ending injury on his podcast.

San Francisco 49ers head coach Kyle Shanahan addressed reporters during a Monday conference call, a day after the team's dominant 38-13 victory over the Chicago Bears. He shared several injury updates ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

NFL Week 15 odds, picks, predictions, TV channel, streaming for Thursday Night Football game between Los Angeles Rams and San ...

The San Francisco 49ers sustained another injury at running back during their Sunday contest against the Chicago Bears.

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve and is likely out for the season after suffering a PCL injury in Week 13 agai ...

The beat-up San Francisco 49ers hope to keep their faint playoff hopes alive when they host the struggling Chicago Bears in ...