SANTA CLARA, CALIFORNIA - JANUARY 22: Christian McCaffrey #23 of the San Francisco 49ers rushes for a touchdown against the ...

RB Christian McCaffrey, playing in just his fourth game since returning from Achilles tendinitis, suffered a PCL injury ...

The San Francisco 49ers' season has been on the brink for weeks, and the Week 13 blowout loss to the Buffalo Bills certainly ...

After coming within a whisker of winning the Super Bowl, the San Francisco 49ers are suffering through a nightmare season in ...

The 49ers are down to one healthy RB, rookie Isaac Guerendo. They will likely elevate Patrick Taylor Jr. from the practice ...

The San Francisco 49ers’ dreadful season got worse in Week 13 when running backs Christian McCaffrey and Jordan Mason both ...

It's going to be another lost season for Christian McCaffrey, but he is not the only San Francisco running back who suffered ...

Head coach Kyle Shanahan shared the latest injury and team updates emerging from the San Francisco 49ers Week 13 matchup ...

McCaffrey suffered a PCL injury during Sunday's loss to the Bills, while Mason goes on IR with a high ankle sprain.

As the San Francisco 49ers confirmed Christian McCaffrey suffered a likely season-ending injury, his backup, Jordan Mason, ...

The 24-year-old Guerendo was a fourth-round pick in the 2024 NFL draft. He transferred to Louisville for the 2023 season ...

San Francisco 49ers head coach Kyle Shanahan revealed Sunday night that the team fears running back Christian McCaffrey ...