This is a preview. Log in through your library . Abstract The fluorophore FM1-43 appears to stain membranes of recycled synaptic vesicles. We used FM1-43 to study mechanisms of synaptic vesicle ...

Jennifer Morgan (Marine Biological Laboratory or MBL) and Dragomir Milovanovic (German Center for Neurodegenerative Diseases (DZNE) have formed a large collaboration at the MBL to understand how ...

Researchers have used cryo-electron tomography to uncover new details of the molecular structure of synaptic vesicles, which help transport neurotransmitters in the brain. The study could inform ...

How do we think, feel, remember, or move? It all depends on transmission of chemical signals in the brain, carried and released by molecular containers called vesicles. In a new study, researchers ...

"Synaptic vesicles are of paramount importance in brain function and they have been studied for decades. However, previous reports have described the molecular composition of an 'average' synaptic ...

Researchers at Johns Hopkins Medicine say they unexpectedly found new information about a protein's special role in getting brain cells to communicate at the right time and place in experiments with ...

Synaptic vesicles are tiny, membrane-enclosed compartments that package and release messenger compounds, such as neurotransmitters, in neurons. Researchers have identified common proteins associated ...

α-synuclein (α-syn) is a small presynaptic protein linked to the pathogenesis of Parkinson’s disease (PD) and related disorders, collectively called synucleinopathies. Phosphorylation of α-syn at ...

During prolonged trains of presynaptic action potentials (APs), synaptic release reaches a stable level that reflects the speed of replenishment of the readily releasable pool (RRP). Determining the ...