Once the most successful mRNA-based LNP was tested in 3D in vitro models, the fluorescent dye continued to facilitate ...

Nucleic acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger RNA (mRNA), immunomodulatory DNA/RNA, and gene-editing guide RNA (gRNA), hold ...

A team at Oregon State University has engineered lipid nanoparticles that deliver messenger RNA to lung tumors while ...

Penn Engineers have modified lipid nanoparticles (LNPs) — the revolutionary technology behind the COVID-19 mRNA vaccines — to not only cross the blood-brain barrier (BBB) but also to target specific ...

Lipid nanoparticles (LNPs) act as carriers for mRNA and CRISPR payloads across a wide range of therapeutic applications, from cancer to inflammatory and genetic diseases. The same delivery system used ...

(A) PDL1Nb, CTLA-4, Luc pDNA construction. (B) IB analysis shows the levels of PDL1Nb or CTLA-4Nb in the SFM of HEK293 cells transfected with PDL1Nb, CTLA-4Nb or Luc expression vectors. Mock: SFM.

A major bottleneck in curing HIV (human immunodeficiency virus) is that the virus can hide in an inactive form within resting white blood cells, which play a crucial role in coordinating the immune ...

Researchers from the Wilmer Eye Institute, Johns Hopkins Medicine Center for Nanomedicine - which designs nanotechnology-based platforms for clinical translation across specialties - developed a ...

Therapeutic mRNA delivered via lipid nanoparticles restored sperm production in genetically infertile mice and produced live offspring without genomic integration. (Nanowerk Spotlight) Male ...