Scientists from Hiroshima University Hospital clarified the mechanism by which YAP/TAZ confers resistance against indisulam. Indisulam induced degradation of RBM39 in YAP/TAZ inactivated cells, ...

Aortic dissection (AD) is a fatal disease resulting from the dysfunction of elastin contractile units, which are composed of extracellular matrix (ECM) and aortic smooth muscle cells (AoSMCs), and ...

Pancreatic cancer, recognized as one of the deadliest cancers, poses a persistent challenge for medical professionals globally due to its aggressive behavior and resistance to conventional therapies.

Researchers from Merck & Co. Inc. have presented the discovery of inhibitors of the YAP/TAZ-TEAD complex as potential anticancer agents. YAP and its paralogue TAZ act as terminal effectors of the ...

The liver's ability to communicate with other organs is crucial for maintaining homeostasis, particularly through signaling pathways. During liver regeneration, communication with organs such as the ...