Certain cells, commonly called excitable cells, are unique because of their ability to generate electrical signals. Although several types of excitable cells exist — including neurons, muscle cells, ...

Ion channels are membrane proteins, which play a principal role in regulating cellular excitability. They are found in virtually all cells, and are of crucial physiological importance. Based on the ...

Today it seems self-evident that neurons make their electrical signals by opening gates of water-filled pores (ion channels) in the plasma membrane. But it was not always so. Remarkably, pore theory ...

Ion channels are attractive drug targets due to their importance in health and disease, but finding ways to target a specific ion channel selectively is a major challenge. Now, researchers have ...

This is a preview. Log in through your library . Abstract The axon initial segment (AIS) of pyramidal cells is a critical region for the generation of action potentials and for the control of ...