A major problem in solid-phase peptide synthesis (SPPS) is aggregation and poor solvation leading to incomplete deprotection and/or coupling steps, resulting in low crude purity peptides. 1 This ...

Modern medicine depends on large, information-rich molecules such as peptides and oligonucleotides. These molecules carry biological instructions that can be directed toward specific disease pathways.

The Peptide-ExplorerLT ™ is designed for scientists who need to optimize and explore linear peptide synthesis. The product is a high-spec flow chemistry system that uses continuous flow. The product ...

Vapourtec's Peptide-Builder, a fully automated, high-throughput benchtop peptide synthesizer, has been designed to redefine solid-phase peptide synthesis (SPPS). Compact, efficient and intuitive, it ...

A recent video produced by Vapourtec highlights the patented automatic Variable Bed Flow Reactor (VBFR) demonstrating fully automated solid phase peptide synthesis. The process begins with swelling ...

SHANGHAI--(BUSINESS WIRE)--AmbioPharm, a worldwide leader in peptide API CDMO services, continues growth to meet capacity demands for late phase and commercial peptide production. A reliable peptide ...

Amide Technologies has raised $16.5 million in venture capital to help commercialize its peptide production process. The process was developed from 2011 to 2017 in the lab of the Massachusetts ...

Cyclic peptides offer enhanced stability and bioavailability, but precise cyclization strategies and specialized synthetic techniques are required to maintain their biological activity. A recent ...

A peptide sequence that performs well at micromole scale may behave unpredictably at gram or kilogram scale. Coupling efficiency, acceptable with high reagent excess, can drop when equivalents are ...

What is it? As the name suggests, nonribosomal peptide synthesis (NRPS) generates polypeptides sans ribosome. The resultant peptides, generally short oligomers of two to perhaps 48 residues, are not ...

Peptide bonds represent a cornerstone in molecular biology. They act as essential chemical linkages that bind amino acids into complex chains, ultimately forming peptides and proteins. These ...