A new review highlights how synthetic biology, AI, and spatial omics could transform ligand-receptor discovery from one-by-one searches into network-level mapping.

Iron is indispensable for oxygen transport, DNA synthesis and energy production, yet free iron is potentially toxic. Cellular uptake of iron is primarily mediated by the transferrin receptor (TfR), ...

Liver X receptors (LXRs) are ligand-activated nuclear transcription factors comprising two isoforms, LXRα and LXRβ, that serve as master regulators of lipid and cholesterol homeostasis. Upon binding ...

New AI‑designed miniproteins precisely modulate GPCR signaling and reveal a new screening system for targeting receptors long ...

Edited by Karen Young Kreeger J.A. Bennett, R. Dingledine, "Topology profile for a glutamate receptor: Three transmembrane domains and a channel-lining reentrant membrane loop," Neuron, 14:373-84, ...

Chronic itch is often described as an "invisible torment." It can persist for weeks or months, severely affecting sleep, ...

"I think PAGER has potential for impact, both in the G protein coupled receptor biology field, and in synthetic circuits or cell-based therapies," said Alice Ting, professor of genetics at the School ...

All cells, whether big or small, short or long, rely on proteins to function properly. In most cells, transporting these ...

Tweaking the numbers of receptors in a key brain area changes the daily rhythms of rest and wake in mice. In humans and other animals, signals from a central circadian clock in the brain generate the ...

Researchers at the Harrington Discovery Institute have identified cellular mechanisms involving Golgi apparatus proteins that ...