Field position will be key, and Seattle averages the worst starting field position in the NFL and have a terrible time flipping the field as a result. The Rams take it 23-20 and the Seahawks will have to likely go on the road for the rest of the season to reach the Super Bowl. Puka Nacua thanks the officials for a well refereed game.

Preview the Week 16 matchup between the Seattle Seahawks and Los Angeles Rams with predictions, odds, over/under, spread, betting lines and more.

Here are five players who must step up against Seattle. With Davante Adams doubtful due to a hamstring injury, Atwell will have a chance to prove that he is worth the $10 million the Rams gave him in the offseason. Atwell has dealt with injuries and has struggled to be a consistent force on the field. Could a breakout game await?

Rams vs. Seahawks will stream nationally on Amazon Prime Video in Week 16 of the 2025 NFL season. Al Michaels and Kirk Herbstreit will call the game from the booth at Lumen Field, with Kaylee Hartung reporting from the sidelines. Streaming options for the game include Amazon Prime Video.

Here's your "Thursday Night Football" primer. The winner of this game gets pole position in both their division and conference.

DraftKings offers $200 in bonus bets if your first $5 bet wins for Seahawks vs. Rams on Thursday Night Football and Warriors vs. Suns

As of this writing, the Rams are now 1.5-point underdogs to the Seahawks after opening as 1.5-point favorites, according to BetMGM. In the middle of the week, this game was a pick ‘em, with both teams at -110 on the moneyline.