There is significant crosstalk between DNA damage response (DDR) pathways and innate immune pathways. Both the individual pathways and their interactions are key areas of interest for the development ...

The immunopathogenesis of viral diseases is a crucial focus in contemporary immunology, reflecting the interplay between viral agents and host immune ...

Innate immune sensors – known as pattern recognition receptors (PRRs) – detect specific molecular components of bacterial or viral intruders. The PRRs forward the signals which results in the ...

In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study from St. Jude Children's Research Hospital, published in Cell, ...

A new study conducted by researchers from the University of Potsdam and the University of Cologne has deciphered the step-by-step assembly of the eukaryotic proteasome. Eukaryotes are organisms whose ...

Innate immune sensors – known as pattern recognition receptors (PRRs) – detect specific molecular components of bacterial or viral intruders. The PRRs forward the signals which results in the ...

A genetics‑guided small molecule called compound 6 gently turns down an overactive immune pathway (CARD9), offering a more precise, durable, and potentially safer treatment strategy for Crohn’s ...

Much like humans generate mountains of garbage, our cells are constantly discarding proteins that are damaged or no longer needed. The cellular waste disposal system called the proteasome is best ...

Scientists generally agree that eukaryotes, the domain of life whose cells contain nuclei and that includes almost all multicellular organisms, originated from a process involving the symbiotic union ...

Cancer-fighting T cells do not simply "run out of energy." They are molecularly reprogrammed. For years, mitochondrial dysfunction has been recognized as a hallmark of exhausted T cells in tumors. Yet ...