Protein low-complexity domains (LCDs) stack together to form dynamic liquid droplets within the cell; alas, some pathogenic mutations in these regions encourage aggregation beyond this temporary ...

Although they are much weaker than the preeminent "covalent" chemical bonds that bind atoms in biological molecules, hydrogen bonds are known to occur at key points along the central "backbone" ...

Since the 1960s, chemists have known about an unusual type of hydrogen bond: one that can form between the amide hydrogen and the carbonyl oxygen in the same amino acid. But it’s been hard to show ...

Researchers in civil and environmental engineering reveal that the strength of a biological material like spider silk lies in the geometric configuration of structural proteins, and the small clusters ...

Replacing a hydrogen bond with a covalent bond boosts the potency of a peptide inhibitor of a key cellular signaling pathway implicated in cancer and other diseases. The signaling protein central to ...

(Nanowerk News) Researchers in Civil and Environmental Engineering at MIT reveal that the strength of a biological material like spider silk lies in the specific geometric configuration of structural ...