We make picks for all 16 NFL games with levels of confidence ahead of Week 16. We’re a week away from Christmas and the NFL playoff race is reaching a fevered pitch. We won’t know every playoff spot after this weekend, but we could see most of the playoff berths locked up by the close of 49ers-Colts on Monday.

That includes two marquee games that will hit us before Sunday. The Los Angeles Rams and Seattle Seahawks play what could be an NFC West title game when the two meet on Thursday Night Football. The Green Bay Packers look to shake off injuries to Micah Parsons and Christian Watson by sweeping their season series with the Chicago Bears on Saturday.

Look for the Panthers and Seahawks to win major NFC battles against division leaders, and for the Niners to get their 11th win.

This will be the second start for Philip Rivers for the Colts after he almost won at Seattle last week. The 49ers are 10-4 and pushing for a playoff spot. They blew out Tennessee last week, but the defense wasn't great. It won't matter as the 49ers will limit Rivers and Brock Purdy will play well. The 49ers keep on winning.

All odds referenced are courtesy of BetMGM as of publish time.

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