Pharmacology: The use of opioid analgesics can lead to constipation due to their effect on intestinal smooth muscle and their interference with the bowel’s normal elimination function.

Peripherally acting mu-opioid antagonists (PAMORA). PAMORAs indicated for the treatment of OIC include naloxegol, naldemedine, and methylnatrexone. These agents are opioid antagonists selective to ...

First Results of NURE-Combo: A Phase II Study of Neoadjuvant Nivolumab and Nab-Paclitaxel, Followed by Postsurgical Adjuvant Nivolumab, for Muscle-Invasive Bladder Cancer Preventive use of naldemedine ...

Symproic significantly improved bowel function and frequency of spontaneous bowel movements in patients receiving opioids compared to placebo. The study highlighted a 47.6% difference in bowel ...

Tsukuba, Japan—Pain relief for patients with cancer is crucial, and opioids, such as morphine, play a vital role. However, constipation, which negatively affects the patient's quality of life, is a ...

A study led by University of Manchester epidemiologists has revealed which opioid painkillers are most likely to be associated with constipation in patients with non-cancer pain. Morphine, oxycodone, ...

Shionogi today announced pivotal phase III study (COMPOSE I) results showing that once-daily treatment with naldemedine significantly improved opioid-induced constipation (OIC) compared to placebo in ...

PALM SPRINGS, California — A peripherally acting oral μ-opioid receptor antagonist is superior to placebo in treating opioid-induced constipation (OIC) and doesn't reduce the analgesic effect of ...

Opioids can cause opioid-induced constipation by slowing down digestion and reducing fluid in the intestines. NSAIDs like ibuprofen can irritate the stomach lining and slow digestion, leading to ...

First Results of NURE-Combo: A Phase II Study of Neoadjuvant Nivolumab and Nab-Paclitaxel, Followed by Postsurgical Adjuvant Nivolumab, for Muscle-Invasive Bladder Cancer This multicenter, ...