Making complicated organic molecules is like solving a Rubik’s cube. Organic chemists need to design sequences of reactions to carefully build up parts of a molecule, while maintaining the structure ...

Organic chemistry students and bench chemists alike rely on the Grignard reaction, a relatively simple way to make carbon-carbon bonds. But even though the reaction was first described 120 years ago, ...

The reaction utilizes an iron catalyst together with an N-heterocyclic carbene (NHC) ligand, which suppresses unwanted side reactions to promote highly selective nucleophile addition. In organic ...

For more than a century, magnesium has been prized as a reactive metal capable of facilitating a range of important organic syntheses—the Grignard reaction, for example. For calcium, which sits just ...