New research has uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's disease. In a first step, two dimeric ...

A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's ...

Please provide your email address to receive an email when new articles are posted on . Gamma-secretase inhibitors destroyed chemotherapy-resistant “mammosphere-forming” breast cancer stem cells in ...

Dish,” to test anti-amyloid therapies. The approach has already been used to screen thousands of compounds and enables more ...

June 15, 2007 (Washington, DC) — A drug that deactivates gamma-secretase, an enzyme involved in amyloid-beta (Abeta) synthesis, appears to be safe and reduces plasma concentrations of Abeta in ...

Based on structural similarities with other targets of the gamma-secretase system, researchers from Columbia University Irving Medical Center in the United States show that the SARS-CoV-2 receptor for ...

A first-in-human, phase I study of an oral hedgehog (HH) pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors. Background: Aberrant Notch signaling is ...

A newly identified compound is a promising candidate for inhibiting the production of amyloids, the abnormal proteins that form toxic clumps, called fibrils, inside the brains of patients with ...

From the Damian Green Lab, in collaboration with the Geoff Hill and Riddell Labs, Translational Sciences and Therapeutics Division and David Coffey, Division of Myeloma, at the University of Miami To ...

Intensity-modulated radiation therapy for pediatric head and neck rhabdomyosarcoma: French preliminary results. Late side effects of neoadjuvant chemotherapy in patients treated for osteosarcoma and ...

T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) are aggressive malignancies derived from neoplastic transformation of precursor T cells. T-ALL accounts for 10–15% ...