Using a variety of laboratory and animal models, the team found that cysteine fuels the production of the antioxidant ...

We owe a lot to tissue resident memory T cells (T RM). These specialized immune cells are among the body's first responders to disease. Rather than coursing through the bloodstream-as many T cells ...

Regulatory T cells (Tregs) are specialized immune cells that help maintain immune tolerance and prevent autoimmune disease.

Scientists have discovered how two transcription factors form a reciprocal regulatory circuit that controls T-cell exhaustion ...

A research team from the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the ...

T cells are essential components of the immune system and play critical roles in immune responses against infections, tumors, and autoimmune diseases. T cells are highly heterogeneous, with distinct ...

An engineered viral protein enhanced the anticancer function of T cells in mice, suggesting a new strategy to improve immunotherapy. Courtney and his team sought to exploit this property of TIP to ...

Immunotherapy has been one of the most transformative treatments for cancer patients in recent decades, shifting the emphasis ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

Five years ago, Nobel laureate Carolyn Bertozzi, PhD, and her team described novel small RNA-glycan conjugates, glycosylated RNAs (glycoRNAs), on the cell surface. These small non-coding RNAs have ...