Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these added golden years are not spent in good health. Aging is a natural part of ...

The cell's endoplasmic reticulum (ER) plays a central role in protein synthesis, folding, and calcium (Ca²⁺) storage. When damaged, ER-phagy (self-eating) removes affected ER regions via ...

Endoplasmic reticulum (ER) proteostasis is regulated by the adaptive unfolded protein response (UPR) pathway, which determines cell fate and maintains cell structure and function Stress (hypoxia, ...

The endoplasmic reticulum is the protein-making factory within cells consisting of tightly stacked sheets of membrane studded with the molecules that make proteins. Now, researchers have refined a new ...

A team of scientists has answered a long-standing question in cell biology, uncovering how the cell’s main energy currency, ATP, is transported into the endoplasmic reticulum (ER). Disrupted energy ...

The synthesis of proteins in the cell is a key process of life. By this means, the genetic code of the genome is translated into the amino acid sequence of proteins. The process is complex – and has ...

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions ...