The Phase 2b study demonstrated a statistically significant dose-response relationship at the primary endpoint following a single administration of MM120 across four dose levels, with improvements ...

The development of robust clinical trial methodologies increasingly relies on advanced statistical frameworks for model selection and the characterisation of dose–response relationships. With modern ...

A large meta-analysis reveals that most antipsychotics achieve near-maximal efficacy at the lower end of recommended dose ranges, typically around 3-5 mg/d of risperidone equivalents.

BRCA1-Associated Protein 1 and Enhancer of Zeste Homolog 2: Pathway Interaction and Therapeutic Intervention in Breast Cancer, Mesothelioma, and Lymphoma Early-phase clinical trials (EPCTs) have been ...

Mo-Rez achieved confirmed objective response rates of 62% in patients with platinum-resistant ovarian cancer. Credit: MMD ...

Creating a Proxy for Baseline Eastern Cooperative Oncology Group Performance Status in Electronic Health Records for Comparative Effectiveness Research in Advanced Non–Small Cell Lung Cancer ...

CytoAgents Inc. completed the dose-limiting toxicity observation for the first cohort in a trial targeting CRS in blood cancer patients. The Safety Review Committee approved dose escalation for the ...

Paclitaxel remains first-line for cutaneous angiosarcoma, but absence of validated second-line therapy creates a major unmet ...

8 Physical Fitness Association of Hong Kong, Hong Kong, People's Republic of China Importance Aerobic exercise is an evidence-based treatment for depression. However, current exercise recommendations ...