Wnt signalling comprises a network of pathways essential to embryonic development, tissue patterning and stem cell maintenance. The canonical branch centres on the stabilization of β-catenin, which ...

Recent evidence suggests that dopamine plays a crucial role in neural development. In a novel study, investigators demonstrated the link between disrupted developmental dopamine signaling and autism ...

Like schools of fish and flocks of birds, our cells can also migrate collectively in coordination with their neighbors. This ...

Targeting the WNT signaling pathway represents a promising strategy for cancer therapy. The field has evolved to include numerous inhibitors currently under preclinical and clinical investigation.

Researchers discovered that disrupted PTH1R signaling drives abnormal cementum growth and tooth-bone fusion in adult ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are essential for a wide range of cellular functions—as enzymes, transporters, ...

LMU researchers have discovered how the interplay between a key protein and an endolysosomal ion channel promotes tumor development in skin cancer. A team led by LMU pharmacologist Professor Christian ...

A team at Huntsman Cancer Institute at the University of Utah (the U) has uncovered a previously unrecognized molecular mechanism by which cells send signals to one another-insight that could help ...

In certain contexts, the Notch receptor may participate in “reverse signaling,” influencing neighboring cells directly.

Researchers at Tulane University, with a team of colleagues from eight other universities, have discovered a new nerve cell signaling mechanism that could transform our understanding of pain and lead ...