Grant D. Schauer, Michael E. O’Donnell, Quality control mechanisms exclude incorrect polymerases from the eukaryotic replication fork, Proceedings of the National Academy of Sciences of the United ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 40 (October 4, 2022), pp. 1-10 (10 pages) Mismatch repair (MMR) is a replication-coupled DNA repair ...

Holliday junctions act as recognition signals near the ORCs of eukaryotic DNA during replication. Other proteins, such as MLL, WRN, 14-3-3, and DEK also show preferential binding.

More information: Lari Pyöriä et al, Unmasking the tissue-resident eukaryotic DNA virome in humans, Nucleic Acids Research (2023). DOI: 10.1093/nar/gkad199 Journal information: Nucleic Acids ...

At school, it's often presented as a tidy double helix but scientists are revealing the varied and intricate shapes of DNA molecules.

Analysis of patient tumor samples and clinical data correlated disease progression with an increase in DNA replication stress response factors. Our findings suggest that many MAPK pathway–mutant ...

Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to ...

Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports . This is the first detailed ...