Figure 1: Large endosomes are surrounded by dynamic coats of F-actin. Figure 2: F-actin coats close over and compress exocytosing cortical granule compartments. For an alternative perspective, 4D ...
A group led by the Department of Cell Biology at the Kidney Research Center, Niigata University revealed that elevated activity of cdc42 is a critical initiation event leading to proteinuria, and ...
Cell polarity is regulated by independent pathways that are controlled by Wnt- or Cdc42-mediated signalling. Now, glycogen synthase kinase 3 (GSK-3), an established component of the Wnt pathway, is ...
(Upper panel) Normal podocytes: Ephrin-B1 at slit diaphragm interacts with nephrin via the extracellular site and with Par6 via the cytoplasmic site. (Lower panel) Podocytes stimulated by anti-nephrin ...
The activation of hepatic stellate cells (HSCs) from a quiescent state is a cause of liver fibrosis and a therapeutic target. HSCs are resident mesenchymal cells located in the space of Disse, ...
The guanine nucleotide exchange factor Cdc24, the GTPase Cdc42, and the Cdc42 effectors Cla4 and Ste20, two p21-activated kinases, form a signal transduction cascade that promotes mitotic exit in ...
Recent research indicates that CDC42 plays a role in the pathogenesis of kidney disorders such as congenital nephrotic syndrome or glomerulosclerosis because it is necessary for the correct function ...
In mice, the Cdc42 gene is necessary for the correct polarity of Sertoli cells that support sperm production, according to a new study. Findings may accelerate efforts to create a non-invasive ...
Sticky spots on cell membranes hold onto the master regulator of cell polarity, helping to ensure that the regulatory protein accumulates in high enough concentrations to trigger cell polarity. Over ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results