SEVERE metabolic acidosis, when it occurs in diabetic patients, is generally the result of excessive hepatic production of acetoacetic and beta-hydroxybutyric acid. Exceptional cases of metabolic ...

(A) Ketone bodies (acetoacetic acid, β hydroxybutyric acid) are typically decomposed into acetyl CoA in the mitochondria and become energy sources through the citric acid cycle. (B) Under myocardial ...

The most important synthetic pathway for γ-hydroxybutyric acid (GHB) entails conversion of γ-aminobutyric acid (GABA) to succinic semialdehyde by mitochondrial GABA transaminase, followed by reduction ...

Researchers have measured the ketone body utilization rate in the heart and confirmed that it decreases when the heart is in a state of reduced blood flow (myocardial ischemia). Ketone bodies ...