Base editing, the process used to make the changes, only nicks one strand of DNA, avoiding the major DNA errors that made ...

Research led by the University of Cambridge Loke Centre for Trophoblast Research has shown that a genome editing technique ...

Base editing in human embryos reveals that NANOG is the one gene required to form every body tissue. Cambridge’s landmark ...

Both CBEs and ABEs have been extensively engineered to improve their efficiency, specificity, and targeting range, enabling a wide variety of base pair conversions across the genome. Base editing can ...

Researchers have found that a new base-editing gene therapy can help treat a rare neurodevelopmental disorder called Snijders Blok–Campeau syndrome caused by mutations in the CHD3 gene. A specialized ...

The researchers used adenine base editing (ABE), a precision gene editing approach that rewrites a single DNA letter without cutting both DNA strands, which preserves genomic integrity and reduces the ...

In 2025, baby KJ Muldoon became the first person to receive a personalized gene editing treatment, which likely saved his life. But the scientific advances that made the groundbreaking treatment ...

Microbiome research has faced a hurdle from the get-go: the inability to edit the microbial genome in vivo. Until now, bacterial genomes had to be modified outside—and reintroduced into—the host ...

A fundamental challenge for cystic fibrosis (CF) gene therapy is ensuring sufficient transduction of airway epithelial cells to achieve therapeutic correction. Gene editing is a method to permanently ...

CRISPR-Cas9 gene editing relies on a guide RNA that binds to a desired DNA sequence and a Cas9 enzyme that cuts both strands of DNA at that site, creating a double-strand break. Scientists edit the ...