Subclonal copy number alterations are a prevalent feature in tumors with high chromosomal instability and result in heterogeneous cancer cell populations with distinct phenotypes. However, the extent ...

One of the challenges in clinical genetics for rare diseases, especially in the era of personalized medicine, is assessing the effect of putative splicing variants on isoform expression in ...

Discover why recessive traits from previous generations can unexpectedly appear in individuals due to genetic inheritance and ...

First clinical authorization for an in vivo Prime Editing therapy from Prime Medicine ---- PM577a targets the H1069Q mutation in the ATP7B ...