This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

Acute appendicitis is the sudden and severe inflammation of the appendix. It can cause pain in the abdomen, and this pain may occur quickly and worsen within hours. The appendix is a narrow tube that ...

For decades, surgical appendectomy has been the standard treatment for acute appendicitis. But nonoperative management with antibiotics is an option for some patients. For acute, uncomplicated ...

In patients with uncomplicated appendicitis, initial antibiotic treatment yielded a true recurrence rate of nearly 38% over 10 years. More than half of the patients treated with antibiotics avoided ...

For patients with uncomplicated acute appendicitis, the noninferiority of oral antibiotics alone compared with a combination of intravenous and oral antibiotics could not be demonstrated in a ...

Appendicitis. Illustration of a human appendix, showing it red and inflamed in appendicitis. The appendix is a narrow finger-shaped tube that branches off the first part of the large intestine (caecum ...

Please provide your email address to receive an email when new articles are posted on . Initial antibiotic treatment was successful in 88% to 95% of patients. At 25 years, 60% treated with antibiotics ...

Ten-year follow-up results showed that 37.8% of patients who received antibiotics versus appendectomy had a true recurrence of appendicitis. Overall, cumulative complication rates at 10 years were ...

Please provide your email address to receive an email when new articles are posted on . Among adults with uncomplicated acute appendicitis, treatment with 7 days of oral moxifloxacin is not noninferior ...

Appendicitis symptoms start with belly pain that moves and intensifies in your lower right side. Without surgery, perforated appendicitis can lead to serious complications like peritonitis or sepsis.