Conservative-leaning Supreme Court justices suggested during oral arguments Wednesday they’re inclined to uphold Tennessee’s ban on gender-affirming care for minors, in a landmark case that could have repercussions nationwide as Republicans have increasingly targeted transgender rights and enacted bans on gender-affirming healthcare for minors.

In U.S. v. Skrmetti, the justices are weighing whether Tennessee’s restrictions on certain gender-related treatments, such as puberty blockers and hormone therapy, can stand as written.