techexplorist9d
Uncovering the genetic basis of rare mutations in Alzheimer’s disease
Alzheimer’s disease is a progressive condition that impairs memory and cognitive function, affecting millions globally.
Reserch sheds light on how mutated PSEN2 accelerates familial Alzheimer's disease progression
Alzheimer's disease is a debilitating condition that slowly robs people of their memory and cognitive abilities, affecting millions of people worldwide.
Nature14d
Membrane trafficking articles from across Nature Portfolio
This latest research reveals that changes in PSEN2 expression accelerate amyloid build-up, disrupt lysosomal function, and weaken synaptic connections. These findings spotlight PSEN2 as a powerful ...
EurekAlert!9d
The genetic roots of rare mutations in Alzheimer’s disease
When the PSEN2 gene is absent or carries a familial Alzheimer-related mutation (middle), the lysosomes become noticeably enlarged. Leuven, 3 December 2024 – Alzheimer’s disease is a ...
Medical Xpress9d
Understanding the genetic roots of rare mutations in Alzheimer's disease
Familial Alzheimer's disease (FAD), a rare inherited form of the disease, is linked to mutations in several genes, including APP, PSEN1, and PSEN2. The impact of PSEN2 mutations has remained less ...
inceptivemind9d
The genetic basis of rare mutations in Alzheimer’s disease
Familial Alzheimer's disease (FAD), a rare inherited form of the condition, is associated with mutations in several genes, ...