This article was originally published on www.si.com/college/oklahoma as Three Matchups No. 13 Oklahoma Must Win Against No. 8 Ole Miss. Oklahoma has a prime opportunity to cement itself as a College Football Playoff contender on Saturday.

The Oregonian/OregonLive sports staff returns with its picks for Week 9 of the 2025 college football season. While Oregon State has a bye this week, the No. 6 Oregon Ducks will host the Wisconsin Badgers at Autzen Stadium on Saturday afternoon.

The SEC's new schedule format pairs Oklahoma with Ole Miss as a permanent opponent, a decision that has surprised many. Fans, media personalities, and even Ole Miss coach Lane Kiffin have expressed confusion over the matchup due to a lack of history or geographical connection.

Lane Kiffin and No. 8 ranked Ole Miss continues preparation for the Rebels' Week 9 matchup against the Oklahoma Sooners, but the program remains in headlines fo

If the Rebels can't prevail against the Sooners, their CFP chances will be in flux for the remainder of the 2025 campaign.

Ole Miss may be walking into an early kickoff buzzsaw in Norman on Saturday if oddsmakers and computer nerds are right with its predictions. FanDuel Sportsbook lists the Sooners (6-1, 2-1 SEC) with a -5.

Oklahoma's defensive expert Brent Venables and Ole Miss's offensive mastermind Lane Kiffin are set for a big showdown on Saturday in the Southeastern Conference.

The No. 14 Oklahoma Sooners face the South Carolina Gamecocks on Saturday, Oct. 18, 2025 at Williams-Brice Stadium in Columbia, S.C.